Finally, by modifying in C. elegans the distribution of the chromatin mark H3K27me3, an alteration observed in certain pediatric gliomas, JNK signaling upregulation was identified as the cause of the ectopic replicative fate in germ cells that carry aberrant H3K27me3 marks (Delaney et al., 2019). This evidence concerns the gene MAPK8 and central nervous system cancer.