Furthermore, in a study on the mechanism of the cerebellum in AD, Singh-Bains et al. found upregulation of neocerebellar amyloid-β when the number of Tau, ubiquitin, or Purkinje cells did not change, which may be related to significant changes in neurovascular and microglial cells at the early stage of AD [46]. Here, MAPT is linked to Alzheimer disease.