In view of the fact that SNHG25 plays an essential role in promoting cancer in several malignant tumours, we aimed to elucidate our hypothesis that SNHG25 functions as an oncogene by promoting osteosarcoma cell proliferation, invasion, and migration through the miR-497-5p/SOX4 axis, thus showing potential as a biomarker and therapeutic target for osteosarcoma. The gene discussed is SOX4; the disease is osteosarcoma.