CD226 and breast carcinoma: Santos revealed that LDL-cholesterol induces epithelial-mesenchymal transition (EMT) by upregulating mesenchymal markers Slug, vimentin, and β-catenin and downregulating adhesion molecules cadherin-related family member 3(CDHR), CD226, Claudin, and Ocludin, thereby promoting migration and invasion of breast cancer cells [46].