Compared with the normal group (N = 431), the hypoalbuminemia group (N = 569) had significant differences in hematocrit (44.4 (10.2) vs. 43.2 (11.2), P = 0.023), serum albumin (35.6 (5.9) vs. 30.2 (6.2), P < 0.001), serum urea (7.2 (4.9) vs. 9.2 (7.7), P < 0.001), serum creatinine (77.0 (57.2) vs. 95.0 (130.0), P < 0.001), serum calcium (2.0 (0.4) vs. 1.8 (0.4), P < 0.001) and APACHE II score ≥ 15 (76 (17.6%) vs. 133 (23.4%), P < 0.001). This evidence concerns the gene ALB and Hypoalbuminemia.