E2F1 and neoplasm: The expression levels of E2Fs (E2F1-8) were all significantly up-regulated in LUAD tissues [14], Wang et al. investigated the expression, prognosis value, mutation, and potential relationship with immunological aspects of E2Fs in LUAD by bio-informatics analysis [14].E2F1 is expressed strongly in 59.8% of ESCC and that the over-expression was correlated with tumor progression, lymph node metastasis, and poor prognosis after surgery [16].