E2F1 and cancer: And, there were significantly association between high expression of E2F1 and the subgroup that non-gender specific cancers (HR = 2.96, 95%CI:1.47–5.91, I2 = 82.8%, *PHeterogeneity = 0.003), so as the subgroup that the number of patients which less than 150 (HR = 4.39, 95%CI:4.05–4.78, I2 = 0.0%, PHeterogeneity = 0.494).