IFNG and Alzheimer disease: Recent meta-analyses of 170 + case–control studies found that inflammatory proteins such as IL-1β, IL-6, IL-18, sTNFR1, IFN-γ, high-sensitivity C-reactive protein (CRP), and α1-antichymotrypsin are elevated in the blood of AD patients, compared to that of neurologically normal individuals [8, 9].