Similar to the pathogenesis of sarcopenia, malnutrition, dysregulation of the receptor activator of nuclear factor kappa-B (NF-κB) ligand (RANKL)/RANK/osteoprotegerin system due to chronic inflammation, and decreased levels of anabolic hormone and 25-hydroxyvitamin D cause an imbalance in the activities of osteoblasts and osteoclasts, leading to osteoporosis [10]. This evidence concerns the gene TNFSF11 and osteoporosis.