To identify the clinical significance of increased m6A levels in pSS patients with dry eye, we analyzed the relationship between the m6A level and the performance of serological indicators in these patients, including ANA, anti-SSA autoantibody, anti-SSB autoantibody, RF, IgA, IgG, IgM, C3, C4, CRP, and ESR expression levels. The gene discussed is ESR1; the disease is dry eye syndrome.