To identify the clinical significance of increased m6A levels in pSS patients with dry eye, we analyzed the relationship between the m6A level and the performance of serological indicators in these patients, including ANA, anti-SSA autoantibody, anti-SSB autoantibody, RF, IgA, IgG, IgM, C3, C4, CRP, and ESR expression levels. This evidence concerns the gene SSB and peeling skin syndrome.