In addition, results suggested that iCD4, sCD8, schistosomiasis, gender, pathological T stage, TNM stage and tumor deposit were independent prognostic factors for OS in the whole cohort; In the NSCRC set, sCD4, tumor budding, gender, pathological T stage and tumor deposit were independent prognostic factors for OS; In the SCRC set, iCD8, lymph node metastasis and tumor deposit were independent prognostic factors for OS. This evidence concerns the gene SCD5 and schistosomiasis.