Whereas EIF4A1 and EIF4EBP1 are responsible for translation [75] and translation repression [77], respectively; but with respect to cancer EIF4A1 promotes metastasis [76], while EIF4EBP1 promotes tumourigenesis when phosphorylated [78] and suppresses tumourigenesis when unphosphorylated [79]. The gene discussed is EIF4A1; the disease is cancer.