In this regard, the inflammatory cancer-associated fibroblasts in colorectal adenocarcinomas, which we found to share extensive transcriptional similarity with the activated lining FLS state, express neutrophil chemoattractants including CXCL1 and CXCL8 and their location was spatially correlated with the accumulation of neutrophils20. Here, CXCL8 is linked to colorectal adenocarcinoma.