In contrast, activated sublining FLS were transcriptionally similar to ACTA2+ myofibroblasts and WNT5B+ fibroblasts in the colon as well as two populations of dermal fibroblasts expanded in scleroderma as compared to healthy skin (CCL19+APOE+CXCL12+ and SFRP2hiPRSS23+THY1+). The gene discussed is APOE; the disease is scleroderma.