With respect to kidney diseases, evidence for a shared genetic signal was detected between metabolite associations at GSTM1 and kidney cancer21; FMO4 and hypertensive chronic kidney disease (CKD); ALPL, CYP2D6 and SLC34A1 as well as ABCG2 and kidney stones; and ABCC4 and urine retention. The gene discussed is ALPL; the disease is nephrolithiasis.