PLS3 and osteoporosis: Compared to the same age group in the total population, patients aged 0 to 24 experienced 4.81 times as many hospital admissions, and DTCs were opened 4.78 times more often for the pediatrics department. This is in agreement with the known onset of osteoporosis at childhood by LRP5, PLS3, and WNT1 pathogenic variants [32].