NF2 and mesothelioma: First, as NF2 deficiency was previously reported as a biomarker of YAP/TAZ dependency and is frequently found in mesothelioma12,29,41–43, we tested GNE-7883 across a panel of NF2-null mesothelioma cell lines and validated that these models are overall responsive to GNE-7883 (Fig. 3h).