WFS1 and Werner syndrome: In another study from China that included 82 clinically diagnosed type 1 patients with negative autoantibodies (GADA, islet antigen 2 antibody, and ZnT8 antibody), normal BMI, and at least one episode of ketosis, 4 patients (4.9%) carried homozygous or compound heterozygous variants of WFS1. They were diagnosed with diabetes at ages ranging from 5 to 22 years and had no additional phenotypes of WS except for diabetes5.