Of interest, a 77-year-old female with ovarian cancer and a germline RAD51C LOF alteration, who had progressed on olaparib, had an 82% decrease in cancer antigen 125 (CA-125) at 6 weeks and an overall RECIST 1.1 PR with complete target lesion (TL) resolution at 19 weeks (Fig. 2b). The gene discussed is RAD51C; the disease is ovarian cancer.