Notably, a patient with advanced CRPC whose tumor had biallelic ATM LOF and was positive for ATM protein had a pathogenic missense mutation in the phosphatidylinositol 3-kinase (PI3K) regulatory domain of ATM (p.R3008H), which is not expected to result in loss of ATM expression (Extended Data Fig. 4b). This evidence concerns the gene ATM and neoplasm.