SETD2 and ovarian cancer: Notably, TRESR also included patients harboring DDR-altered genes for which no targeted standard-of-care therapy exists, such as SETD2. The response in a patient with SETD2-altered ovarian cancer may reflect the relevant role of SETD2 in suppressing DNA damage and replication stress through regulation of nucleosome stability41 and by maintaining cellular dNTP levels during DNA replication42.