To clarify whether MTAP-ANRIL induced SNAIL1, N-cadherin and Cyclin B1/Cyclin D1 expression via the JNK and p38 signaling pathways, MTAP-ANRIL melanoma cells were treated with a JNK inhibitor (SP600125) and a p38 inhibitor (SB203580). This evidence concerns the gene MAPK8 and melanoma.