Our data revealed that all carriers with the risk allele G showed increased IRF8 expression compared to carriers with allele A. Furthermore, this reQTL is in LD to GWAS-SNPs associated with inflammatory bowel disease (rs11641016, r2 = 0.86)24, systemic lupus erythematosus (rs11117433, r2 = 1.0)25 and multiple sclerosis (rs17445836, r2 = 1.0)26. The gene discussed is IRF8; the disease is multiple sclerosis.