A disease-associated SNP from GWAS for primary biliary cholangitis, inflammatory bowel disease, systemic lupus erythematosus, and multiple sclerosis was in strong LD to a reQTL that regulated expression of IRF8. Irf8, a key factor for dendritic cell, monocyte, and macrophage maturation, was described to influence the genetic risk for susceptibility to several chronic inflammatory diseases43–45. Here, IRF8 is linked to multiple sclerosis.