HMGCR and melanoma: Firmly aligned with our previous work on how reduced PGC1α levels promotes increased metastatic behavior of melanoma cells15, integrin receptors were here also found upregulated in the chronic treated BRAF-inhibitor resistant melanoma cells (Fig. 1e; Supplementary Fig. 4e), and accordingly determined to be PGC1α-dependent at the RNA level (Supplementary Fig. 9a), but unaffected by HMGCR-inhibitor treatment (Supplementary Fig. 9b).