While ectopic expression of RAB6B, or RAB27A, partially reversed the observed statin sensitivity, co-expression of RAB6B and RAB27A essentially rescued growth inhibition by statin treatment, as demonstrated using in vitro cell proliferation and in vivo tumor xenograft growth measures (Fig. 3f, g; Supplementary Fig. 5b, c). Here, RAB27A is linked to neoplasm.