Among these genes, IGF2BP1 have been proven to be associated with metastasis in various types of human cancers16, 17; PABPC1L is not only related to prognosis of prostate cancer, also the depletion of which could inhibit the migration of human colorectal cancer cells18, 19; however, the role of SNRPA1 in LUAD has not been elucidated. Here, IGF2BP1 is linked to Familial prostate cancer.