CTSB and Schistosomiasis japonica: In recent years, the immunodiagnostic techniques of schistosomiasis japonica have developed rapidly, many novel schistosome antigens for enzyme-linked immunosorbent assay with both high sensitivity and specificity and has been discovered, such as, S. japonicum recombinant phosphoglycerate mutase (rSjPGM) [51], S. japonicum Saposin-like protein 4 (SjSAPLP4) and SjSAPLP5 [25], S. japonicum cathepsin B (SjCatB) [52], SjScP25 [44].