Immunostaining of viral ORF2 antigen by 2G8 antibody [20] suggested that Kernow C1/p6 infection was enhanced upon PRMT5 or WDR77 knockdown (Fig 3B), which was also supported by the flow cytometry data (Fig 3C) as evidenced by increased HEV infection (ORF2 positive cells) upon PRMT5 and WDR77 knockdown. The gene discussed is WDR77; the disease is infection.