FGF1 and cardiac hypertrophy: Also, whole body knockout of miR-27b was found to attenuate pressure overload-induced cardiac hypertrophy via FGF1 (Li et al., 2022), but this could be due to extracardiac effects mediated by miR-27b-3p such as adipocyte browning (Yu et al., 2018; Sun and Trajkovski, 2014; Kong et al., 2015).