ENPP2 and colorectal cancer: Interestingly, ENPP2 of lipid metabolism gene was reported to enhance the cytokine production (Grzes et al., 2021) and was overexpressed during chronic inflammation (Argaud et al., 2019), and it was enriched in the abdomen skin, while LPCAT2 of the other lipid metabolism gene under study was positively correlated with lipid droplet content in colorectal cancer (Cotte et al., 2018), which was mainly highly expressed in back and shoulder skin.