Several clinical trials have shown widespread activation of the immune inflammatory response in groups of patients with depressive disorders (10, 11), and meta-analyses have shown that antidepressants reduce some markers of peripheral inflammation, such as significantly reduced levels of peripheral blood interleukin-1β (IL-1β), IL-6, TNF-α and interleukin-10 (IL-10) (10). This evidence concerns the gene IL6 and depressive disorder.