We first analyzed the expression profiles of 363 FAM family genes in UCEC tumor tissues (n = 552) and paracancerous tissues (n = 35) using the “DESeq2” R package, resulting in 98 differentially expressed FAM family genes (DE-FFGs), of which 57 were upregulated and 41 were downregulated (|log2FC|>1, adjusted p-value <0.05) (Figure 2A; Supplementary Table S1). The gene discussed is USP9X; the disease is neoplasm.