CD4 and cancer: In the low-risk group, upregulation of activity was observed for most steps in the cycle, including cancer cell antigen expression (step 2), initiation and activation (step 3), and transport of immune cells to the tumor (step 4) (CD4+ T-cell recruitment, CD8+ T-cell recruitment, T cell recruitment, dendritic cell recruitment, basophil recruitment, Th22 cell recruitment, macrophage recruitment, Th2 cell recruitment, Treg cell recruitment, monocyte recruitment, neutrophil recruitment, and Th17 recruitment).