CRC is a suitable model to explore these interactions owing to the downstream regulation of hepsin, which depends on the Ras/Erk1/2 signaling pathway (Tervonen et al., 2021), as well as the worse prognosis and greater thrombotic risk associated with the activation of this signaling pathway (Ades et al., 2015; Ottaiano et al., 2020). Here, HPN is linked to colorectal carcinoma.