The results obtained in the plasma of the patients and in vitro in thrombin generation assays, together with the fact that thromboembolic diseases are often associated with metastasis (Carmona-Bayonas et al., 2019), led us to hypothesize that some TTSPs, including hepsin, contribute to hypercoagulability in vivo by generating thrombin at the boundary phase of the tumor invasion and migration front, together with other mediators (Razak et al., 2018; Reddel et al., 2019). This evidence concerns the gene HPN and Thromboembolism.