It should be noted that the 6q21 region encoding FOXO3 is frequently deleted in DLBCL (with deletions of 6q21-q22 occurring in 40% of ABC-DLBCL cases and 22% of GCB-DLBCL cases) (90) and is associated with adverse prognosis (91). The gene discussed is FOXO3; the disease is diffuse large B-cell lymphoma.