No driver mutations have been characterised within FOXO3, however five missense VUS mutations have been identified within exon 1, with one mutation affecting a putative phosphorylation site, Ser26 within marginal zone lymphoma, DLBCL, chronic lymphocytic leukemia (CLL) and BL (Figure 1) (89). The gene discussed is FOXO3; the disease is B-cell chronic lymphocytic leukemia.