Additionally, constitutively active FOXO1 induced apoptosis and cell cycle arrest, partnered with increased expression of FOXO targets CDKN1B and BCL2L11. This study concluded that FOXO1 behaves as a tumour suppressor, and that cHL cells actively reduce FOXO1 levels to aid in disease progression (133). The gene discussed is BCL2L11; the disease is neoplasm.