FOXO1 and cancer: Of note, somatic point mutations of FOXO1 occur more frequently across B cell malignancies than other cancers, and within B cell malignancies occur predominantly in Burkitt’s lymphoma (BL), follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL), with a frequency of ~11%, 6% and ~5% respectively (Figures 4A, B (16–18, 83)).