Remarkably, we found the small effect on Ifnb1 to have a substantially larger effect on the frequency of viral infection, as knockdown of JMJD2d increased viral susceptibility to VSV-GFP approximately 2.5-fold, while overexpression resulted in a 2.5-fold increase in resistance to a Sindbis-mCherry virus (Figure 2C). Here, IFNB1 is linked to viral infectious disease.