Genetically, CGD and CGD-like disease are heterogeneous diseases with an X-linked recessive form caused by mutations in CYBB gene (2) and an autosomal recessive form caused by mutations in the CYBA, CYBC1 (3), NCF1, NCF2, NCF4, and RAC1/2 genes (4, 5). The gene discussed is CYBA; the disease is chronic granulomatous disease.