HLA-DRB1 and autoimmune polyendocrinopathy: After comparing the HLA-DRB1 and HLA-DQB1 profiles of primary APS and secondary APS patients, it was found that the frequency of DRB1*13, DQB1*06 and DQB1*0302 alleles was high in primary APS patients, while the DQB1*0301 allele was rare (59).