Inhibition of the anti-tumor immune response by TAMs and tumor cells occurs by downregulating MHC expression, suppressing T-cell activation and expansion, inducing T-cell anergy, activating suppressive regulatory T-cells (Treg) and myeloid-derived suppressor cells (MDSC), and driving TAMs to the immunosuppressive M2 phenotype (18). This evidence concerns the gene HLA-C and neoplasm.