In TME or TIME infiltrated B cells under the influence of IL-6, IL-1β, IL-12p35, and low oxygen (tumor-promoting molecules), which polarize to regulatory B cells (Bregs), producing TGF-β, granzyme B (GZMB), IL-10, and IL-35, which promote tumor growth and metastasis (398–402). This evidence concerns the gene TGFB1 and neoplasm.