Also, the tumor-released Wnt5 molecule triggers PPAR-γ activation through β-catenin, which activates FAO by upregulating carnitine palmitoyltransferase-1A (CPT1A, a fatty acid transporter) in TADCs and induces a tolerogenic phenotype and secrete IDO to create an immunosuppressive TIME by upregulating Tregs (238, 239). The gene discussed is IDO1; the disease is neoplasm.