To prevent overfitting, lasso regression and multivariate COX regression analysis were performed on these genes, and nine core genes (CALR, CASP6, CCDC80, CSPG4, FASN, HMGA1, ITGA3, RAC3, RAD9A) were identified in BLCA, all of which were considered prognostic indicators (Table S4; Figures 3B, C). The gene discussed is CCDC80; the disease is bladder transitional cell carcinoma.