C5AR2 and acquired epidermolysis bullosa: Recently, we published that neutrophils isolated from C5ar2–/– mice exhibit a changed expression pattern in Fcγ receptors, resulting in a decreased release of ROS – critical drivers of tissue destruction in EBA pathogenesis (47, 56) – after stimulation with ICs consisting of murine COL7C and rabbit anti-mouse COL7 IgGs (35).