confirmed that rs2431697, a functional miR-SNP located in the intergenic region between the pituitary tumor transforming gene 1 (PTTG1) and MIR146A genes that reduces the expression of miR-146a by 50%, was significantly associated with systemic lupus erythematosus (SLE) in a population of 1324 patients and 1453 controls (61). Here, PTTG1 is linked to systemic lupus erythematosus.