We found that ARNTL2 is associated with cycle-related pathways in human cancers, such as ‘Cell Cycle,’ ‘Signaling by Rho GTPases, Miro GTPases and RHOBTB3,’ and ‘Vesicle-mediated transport.’ In addition, ARNTL2 was extensively involved in immunomodulation-related pathways, particularly those related to adaptive immunity, innate immunity, and cytokine signaling in the immune system. The gene discussed is RHOBTB3; the disease is cancer.