Results from both databases showed that in most malignancies, ARNTL2 expression positively correlated with the infiltration of immunosuppressive-related cells, including regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), but suppressed the infiltration of immune-promoting-related cells such as B cells, NK/NKT cells, CD4+ T cells, and CD8+ T cells. The gene discussed is CD8A; the disease is neoplasm.