Targeting GPLD1 has been found to inhibit the proliferation of non-small cell lung cancer cells mediated by p38 MAP kinase (43) Knockdown or silencing of FABP5 has been shown to reduce the proliferation and invasiveness of PC cells in vitro and reduce tumor growth and metastasis in vivo (44). The gene discussed is GPLD1; the disease is pachyonychia congenita.