We found Fas+PNA+ GC B cells and IgD-CD138+ PC B cells formed robustly in the popLNs after the headless HA VLP immunization (Figures 1C, D), indicating that the headless HA VLP immunization could induce the production of HA specific antibodies and might contribute to immune protection against A/PR/8/1934 infection. The gene discussed is SDC1; the disease is infection.