HAVCR2 and neoplasm: The immune checkpoints mainly include programmed death-1 (PD-1), cytotoxic T lymphocyte associated antigen 4 (CTLA-4), T cell Immunoglobulin domain and Mucindomain-3 (TIM-3), which can induce immunosuppressive responses of T cells and promote T cell failure by binding with corresponding ligands on the surface of tumor cells.