The results showed the immune and inflammation-related pathways:IL2-STAT5-signaling, Allograft-rejection, Inflammatory Response, IL6-JAK-STAT3-signaling, TNFA-signaling-via-NFKB, IFN-α-Response and IFN-γ-Response, and TMSB10 was significantly and positively enriched in various tumors, especially in BLCA, GBM, KICH, KIRC, PCPG and THCA. The gene discussed is STAT3; the disease is bladder transitional cell carcinoma.