IRF4 and plasma cell myeloma: Research now generally agrees that IMIDs have both tumor and immune dual targeting effects (46).IMiDs have directed cytotoxic effects on myeloma cells, inducing growth arrest and apoptosis of MM cells, which is associated with downregulation of interferon regulatory factor 4(IRF4) and cereblon-dependent degradation of the transcription factors Ikaros/Aiolos (IKZF1/3) (47, 48).