Myeloma cells express programmed cell death ligand 1(PD-L1) and CD155 ligand, which directly lead to T cell depletion by binding to the T cell surface receptors programmed cell death protein 1(PD-1) and T cell immunoglobulin and ITIM domain(TIGIT), respectively (10). The gene discussed is PDCD1; the disease is plasma cell myeloma.