IFNGR is subjected to degradation by the proteasome through GSK3b (70), ELF5/FBXW7 (46) and N-glycosylation (reversible by all-trans retinoic acid induces MGAT expression) (71) mediated ubiquitination in monocytic cell lines, breast cancer, and colorectal cancer respectively. The gene discussed is IFNGR1; the disease is colorectal cancer.