Abnormal GSDMD activation can cause persistent inflammation, which has been implicated in various inflammatory diseases, including ischemic stroke (19, 20), familial Mediterranean fever (FMF) (21), neonatal-onset multisystem inflammatory disease (NOMID) (22), experimental autoimmune encephalitis (EAE) (23), sepsis (24, 25), nonalcoholic fatty liver disease (NAFLD) (26), cancer (27–29), human immunodeficiency virus (HIV) infection (30), neurodegenerative diseases such as Alzheimer’s disease (AD) (31, 32) and Parkinson’s disease (PD) (33). The gene discussed is GSDMD; the disease is neurodegenerative disease.