IRAK1 and peeling skin syndrome: Increased expression of miR-146a and miR-146b and the gene of TRAF6 in patients with pSS compared to healthy controls. Decreased expression of IRAK1 gene suggests transcriptional repression of IRAK1 in PBMC of pSS patients, whereas the other NF-κB pathway-regulating gene, TRAF6, is overexpressed.