Significantly lower IgM anti-PC but not anti-MDA was seen in MCTD compared to HC. No significant difference in levels of anti-PC nor anti-MDA was identified between disease groups, but low levels of IgM were more prevalent in MCTD, SLE, SjS, SSc and UCTD, more for anti-PC than anti-MDA. This evidence concerns the gene CD40LG and Schwartz-Jampel syndrome.