MiR-155 is regarded as a central modulator of T-cell responses. This study evaluated the expression rate of miR-155 and its functional linked gene (SOCS1). MiR-155 and SOCS1 gene was both overexpressed in the PBMC of patients with pSS. However, there was no significant correlation between expression values of SOCS1 and miR-155 in the pSS patients. Here, SOCS1 is linked to peeling skin syndrome.