Nine proteins were significantly differently expressed between pSS with NMOSD and pSS without NMOSD). Serum levels of clusterin and complement factor H (CFH) were further verified by ELISA. Serum clusterin was higher in NMOSD with pSS than without (298.33 ± 184.52 vs. 173.49 ± 63.03 ng/ml, p < 0.01), while the levels of CFH were lower in pSS patients with NMOSD than without. This evidence concerns the gene CFH and peeling skin syndrome.