Higher levels of miRNAs monocytes from patients with SS than in healthy controls. MiR-34b-3p was differentially expressed between SS patients and healthy controls and RA. Higher levels of miR4701-5p and miR-3162.3p in SS patients. QRT-PCR supported co-regulation of miR-34b-3p, miR-4701-5p, miR-609, miR-300, miR-3162-3p, and miR-877-3p in SS monocytes (43%) in comparison with SLE (5.8%) and RA (5.6%). MiRNA-target pathway predictions identified SS-associated miRNAs appear to preferentially target the TGFβ signaling pathway as opposed to the IL-12 and Toll-like receptor/NFkB-pathways. This evidence concerns the gene NFKB1 and synovial sarcoma.