The effects of LOXL2 on lung fibroblast proliferation and fibrosis development in mice with bleomycin (BLM)-mediated pulmonary fibrosis and the association of LOXL2 in the advancement of pulmonary fibrosis via the TGF-β1/Smad signaling pathway have not been adequately studied (34, 35). The gene discussed is LOXL2; the disease is pulmonary fibrosis.