Moreover, researchers (57) observed that pretreatment with linoleic acid for 24 hr suppressed mRNA expression of COX-2 in BV2 microglial cells following exposure to Aβ42 oligomers for 1 hr but not 4 hr, indicating the short-term protective effect of linoleic acid against neuroinflammation in an AD model. The gene discussed is PTGS2; the disease is Alzheimer disease.