Given obesity is more prevalent among Iranian women and no evidence is available on the possible relationships between the DQI-I and inflammatory markers, this study aimed to examine associations between the DQI-I and inflammatory markers, including MCP-1, hs-CRP, IL-1β, Gal-3, HOMA-IR, TGF-β, and PAI-1, in Iranian overweight and obese women. This evidence concerns the gene LGALS3 and obesity due to melanocortin 4 receptor deficiency.