Interestingly, high-fat diet downregulated HIF-1 signaling pathway, which regulated glucose catabolism and energy metabolism, Fatty acid synthesis, ROS levels (68), and upregulated novobiocin biosynthesis, Cationic antimicrobial peptide (CAMP) resistance, monobactam biosynthesis, pathogenic Escherichia coli infection, shigellosis, and vibrio cholerae infection. Here, CAMP is linked to shigellosis.