The KEGG enrichment analysis revealed that a lot of target genes strongly related with lipid and atherosclerosis, fluid shear stress and atherosclerosis, human cytomegalovirus infection, and hepatitis B. Intestinal mucosal damage is one of the main causes of immunosuppression, and the target genes leading to immunosuppression were mainly T-bet and GATA3, which may be related to the immune regulation (26–28). Here, GATA3 is linked to hepatitis B virus infection.